Avoid alcoholic beverages. Possible risk of cardiorespiratory collapse. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. lorazepam decreases effects of succinylcholine by pharmacodynamic antagonism. Consider decreasing the dose of these drugs when given coadministered with methylphenidate. %%EOF Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression). Use Caution/Monitor. Use Caution/Monitor.lorazepam, loxapine inhaled. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence. WebIV to PO Pharmacy Conversion Protocol Inclusion Criteria for IV to PO Conversion: Infections that Require IV Antibiotics Must satisfy below criteria: Tolerate oral diet or 20002023 Unbound Medicine, Inc. All rights reserved, TY - ELEC Overdose is less probable; and, most of all. commonly, these are "preferred" (on formulary) brand drugs. Risk for sedation increased if flibanserin is coadministration with other CNS depressants. Consult your pharmacist or local waste disposal company. Retrospective cohort study evaluating the effectiveness and safety of benzodiazepine conversion calculations embedded within an institution-specific clinical pathway for sedation and weaning of mechanically ventilated pediatric patients. chlorpheniramine and lorazepam both increase sedation. E#]'h>B^L7a$$KAySOPs ,zKMH3 Post conversion, one patient (1.4%) had increased seizure activity, and four patients (5.6%) required fluid boluses secondary to tachycardia or dehydration, but not hypotension. :T. Risk for sedation increased if flibanserin is coadministration with other CNS depressants. Patient demographics, benzodiazepine dose escalations, as needed benzodiazepine requirements, and severe adverse events within 48 hours of conversion were assessed. lorazepam decreases effects of rapacuronium by pharmacodynamic antagonism. Accessibility Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)lorazepam and midazolam both increase sedation. Effect of interaction is not clear, use caution. Monitor Closely (1)lorazepam and doxylamine both increase sedation. Maintenance: 900-1800 mg/day administered in 3 divided doses; doses of up to 2400 mg/day have been tolerated in long-term clinical studies; up to 3600 mg/day has been tolerated in short-term studies. Monitor Closely (1)brexanolone, lorazepam. Monitor closely for signs of respiratory depression and sedation. Y1 - 2016/12/19/ Avoid or Use Alternate Drug. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any unlikely but serious side effects, including: mental/mood changes (such as hallucinations, depression, thoughts of suicide), trouble speaking, vision changes, unusual weakness, trouble walking, memory problems, signs of infection (such as sore throat that doesn't go away, fever).Get medical help right away if you have any rare but very serious side effects, including: yellowing eyes or skin, seizures, slow/shallow breathing.This medication can rarely have the opposite of its usual calming effect. unspecified interaction mechanism. x}n y)Zn91Iv l38Y8bIkYbX$=x:9\>?}st_~xOo^\~dt&&=\~o~g/}~y%;]V|s{h+j/~\f'iqriwZgI~IOk[b,n6'K+%Y{Y?k{]U4{H}mWRa |3}ktz_>iCy>VbZ{SZ(_!> _~{pz.5'Kxo'wW0P*okGa? Benzodiazepines are often used to bridge patients who are starting an "antidepressant" for anxiety, since the therapeutic effects may be delayed, and patients may experience stimulating side effects initially. . lorazepam and quazepam both increase sedation. There have been postmarketing reports of coma and death with coadministration of buprenorphine and benzodiazepines. etomidate and lorazepam both increase sedation. Minor/Significance Unknown. EPS risk. Use Caution/Monitor. Properly discard this product when it is expired or no longer needed. Paradoxical reactions (anxiety, excitation, agitation, hostility, aggression, rage), Use of injectable dosage form in premature infants (contains benzyl alcohol), Concomitant use of benzodiazepines, including lorazepam, and opioids may result in profound sedation, respiratory depression, coma, and death (see BBW), Advise both patients and caregivers about the risks of respiratory depression and sedation when lorazepam is used with opioids; advise patients not to drive or operate heavy machinery until the effects of concomitant use with the opioid have been determined, Use of benzodiazepines, including lorazepam, both used alone and in combination with other CNS depressants, may lead to potentially fatal respiratory depression, Not recommended for use in patients with primary depressive disorder or psychosis, Injection contains benzyl alcohol associated with potentially fatal "gasping syndrome" in neonates and an increased incidence of kernicterus, particularly in small preterm infants; if patient requires more than recommended dosages or other medications containing this preservative, practitioner must consider daily metabolic load of benzyl alcohol from combined sources, Prolonged use may lead to physical and psychological dependence especially in patients with history of alcohol or drug abuse; risk of dependence is decreased with short-term treatment (eg, 2-4 weeks); evaluate need for continued treatment prior to extending therapy duration, Use of drug, particularly in patients at elevated risk, necessitates counseling about risks and proper use of drug along with monitoring for signs and symptoms of abuse, misuse, and addiction; do not exceed recommended dosing frequency, Avoid or minimize concomitant use of CNS depressants and other substances associated with abuse, misuse, and addiction (eg, opioid analgesics, stimulants); advise patients on proper disposal of unused drug; if a substance use disorder is suspected, evaluate patient and institute (or refer them for) early treatment, as appropriate, For patients using treated more frequently than recommended, to reduce risk of withdrawal reactions, use a gradual taper to discontinue therapy (a patient-specific plan should be used to taper the dose), Patients at an increased risk of withdrawal adverse reactions after benzodiazepine discontinuation or rapid dosage reduction include those who take higher dosages, and those who have had longer durations of use, In some cases, benzodiazepine users have developed a protracted withdrawal syndrome with withdrawal symptoms lasting weeks to more than 12 months, Use caution in patients with history of suicide attempt or drug abuse, Do not withdraw abruptly after prolonged use; terminate dosage gradually, Use caution in patients with impaired gag reflex, May cause CNS depression, impairing physical and mental abilities; caution patients to not operate dangerous machinery or motor vehicles, Use caution in patients with respiratory disease, including COPD or sleep apnea, Hyperactive or aggressive behavior and other paradoxical reactions reported with use, Caution patients that tolerance for alcohol and other CNS depressants will be diminished, There is a pregnancy registry that monitors pregnancy outcomes in woman exposed to psychiatric medications; healthcare providers are encouraged to register patients by calling the National Pregnancy Registry for Psychiatric Medications at 1-866-961-2388 or visiting online at https://womensmentalhealth.org/pregnancyregistry/Neonates born to mothers using benzodiazepines late in pregnancy have been reported to experience symptoms of sedation and/or neonatal withdrawal; available data from published observational studies of pregnant women exposed to benzodiazepines do not report a clear association with benzodiazepines and major birth defects, Benzodiazepines cross the placenta and may produce respiratory depression, hypotonia, and sedation in neonates; monitor neonates exposed to this medication during pregnancy or labor for signs of sedation, respiratory depression, hypotonia, and feeding problems, Monitor neonates exposed to therapy during pregnancy for signs of withdrawal; manage these neonates accordingly, Advise pregnant females who are administered this medication late in pregnancy that therapy can result in sedation (respiratory depression, lethargy, hypotonia) and/or withdrawal symptoms (hyperreflexia, irritability, restlessness, tremors, inconsolable crying, and feeding difficulties) in newborns; instruct patients to inform their healthcare provider if they are pregnant, There are insufficient data regarding obstetrical safety of parenteral lorazepam, including use in cesarean section; such use, therefore, is not recommended, This drug is present in breast milk; there are reports of sedation. Use Caution/Monitor. ID - 787140 butabarbital and lorazepam both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Benzodiazepines. Use Caution/Monitor. Comment: Teduglutide may increase absorption of concomitant PO medications; caution with with drugs requiring titration or those with a narrow therapeutic index; dose adjustment may be necessary. Minor (1)levofloxacin increases levels of lorazepam by decreasing metabolism. Monitor Closely (1)lorazepam and flibanserin both increase sedation. Possible risk of cardiorespiratory collapse. Use Caution/Monitor. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. Use Caution/Monitor. Minor/Significance Unknown. T1 - Benzodiazepines Monitor Closely (1)lorazepam increases and dopamine decreases sedation. Use Caution/Monitor. Use Caution/Monitor. S;~.>J;UKF.3`:3YAz Use Caution/Monitor. Either increases toxicity of the other by sedation. Profound sedation, respiratory depression, coma, and death may result if coadministered. Profound sedation, respiratory depression, coma, and death may result if coadministered. Otherwise, call a poison control center right away. Monitor Closely (1)lasmiditan, lorazepam. A double-blind, randomized comparison of i.v. Coadministration may potentiate the CNS-depressant effects of each drug. To help you remember, use it at the same time(s) each day.Do not suddenly stop using this drug without consulting your doctor. Use Caution/Monitor. Use Caution/Monitor. The maximum dose is 4 mg/day. Effect of interaction is not clear, use caution. Continuously monitor vital signs during sedation and recovery period if coadministered. This drug is available at a middle level co-pay. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. lorazepam and pholcodine both increase sedation. Use Caution/Monitor. Do not double the dose to catch up. Monitor Closely (1)sevoflurane and lorazepam both increase sedation. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Conclusions: Use Caution/Monitor. Modify Therapy/Monitor Closely. modify the keyword list to augment your search. lorazepam and marijuana both increase sedation. Use Caution/Monitor. lorazepam increases and dexmethylphenidate decreases sedation. WebNot technically IV = PO but if pt. Use Caution/Monitor. Barr J, Zomorodi K, Bertaccini EJ, Shafer SL, Geller E. Anesthesiology. Use Caution/Monitor. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Serious - Use Alternative (1)benzhydrocodone/acetaminophen, lorazepam. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Benzodiazepines may be beneficial for long-term use in refractory cases. Use Caution/Monitor. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Please enable it to take advantage of the complete set of features! dosing with pediatric epilepsy staff IV formulation under FDA review, expected 2021 Phenytoin (IV) is non-formulary Administer same total daily dose divided Use Caution/Monitor. Alprazolam: Safety has not been established in children, Chlordiazepoxide: Not recommended for children younger than 6 years of age. As Theoretical interaction; some species of sage may cause convulsions. Monitor Closely (1)ketamine and lorazepam both increase sedation. 3 0 obj Patient demographics, Use Caution/Monitor. Use Caution/Monitor. Coadministration enhances CNS depressant effects. Use Caution/Monitor. Studies have shown that the combination of benzodiazepines and buprenorphine altered the usual ceiling effect on buprenorphine-induced respiratory depression, making the respiratory effects of buprenorphine appear similar to those of full opioid agonists. Use Caution/Monitor. Use Caution/Monitor. <>>> Use Caution/Monitor. Effect of interaction is not clear, use caution. Either increases toxicity of the other by pharmacodynamic synergism. 2 0 obj Minor/Significance Unknown. lorazepam and loxapine both increase sedation. A1 - Kim,Paul,M.D., Ph.D. Use Caution/Monitor. Monitor Closely (1)lorazepam and iloperidone both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. A: Generally acceptable. This drug is available at the lowest co-pay. Effect of interaction is not clear, use caution. Use Caution/Monitor. lorazepam and eucalyptus both increase sedation. Objectives: IV to PO Conversion Possible If: (ALL Criteria Should be met to Take this medication exactly as prescribed to lower the risk of addiction. Oxazepam (Serax): the initial dose is 10-15 mg daily; the dose can be increased by 10 mg daily in divided doses (three times a day); the usual therapeutic dose is 90 mg total/day, with three times a day dosing. Use Caution/Monitor. Effect of interaction is not clear, use caution. Monitor Closely (1)lorazepam and ziprasidone both increase sedation. xb```i\ cc`a4xq`1 cfLk2^eMab\`Y9N"Nykf46tH h)i:b4Y,Q!a6[CNbaP+" lorazepam and loxapine inhaled both increase sedation. Use Caution/Monitor. Monitor Closely (1)lorazepam and buprenorphine buccal both increase sedation. The dosage is based on your medical condition, age, and response to treatment.If directed by your doctor, use this medication regularly in order to get the most benefit from it. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Other (see comment). prescription products. Rapid onset of 3 to 10 minutes advantageous in severely agitated violent patients. Wolters Kluwer Health lorazepam and meperidine both increase sedation. Monitor Closely (1)lorazepam increases and dextroamphetamine decreases sedation. Use Caution/Monitor. Use Caution/Monitor. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Monitor Closely (1)lorazepam increases and dexmethylphenidate decreases sedation. Use Caution/Monitor. Use Caution/Monitor. Minor (1)esomeprazole increases levels of lorazepam by decreasing metabolism. This conversion from intravenous (IV) to oral (PO) thera-py has been practiced in an uncon-trolled fashion since the earliest years of the anti-infective era. Modify Therapy/Monitor Closely. lorazepam increases and benzphetamine decreases sedation. Use Caution/Monitor. Minor/Significance Unknown. Monitor Closely (1)diphenhydramine and lorazepam both increase sedation. Monitor Closely (1)lorazepam increases and armodafinil decreases sedation. lorazepam increases and epinephrine racemic decreases sedation. Monitor Closely (1)lorazepam increases and modafinil decreases sedation. Modify Therapy/Monitor Closely. Monitor Closely (1)lorazepam increases and epinephrine decreases sedation. lorazepam decreases effects of atracurium by pharmacodynamic antagonism. Additive CNS depression. Use Caution/Monitor. Minor (1)serdexmethylphenidate/dexmethylphenidate increases effects of lorazepam by decreasing metabolism. endobj Use Caution/Monitor. Use Caution/Monitor. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Effect of interaction is not clear, use caution. 81 28 Well, the benzodiazepine conversion calculator has got your back! Crit Care Med. Use Caution/Monitor. Monitor Closely (1)estazolam and lorazepam both increase sedation. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Monitor Closely (1)lorazepam and methocarbamol both increase sedation. Monitor Closely (1)difelikefalin and lorazepam both increase sedation. f[ey 0000008055 00000 n Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Monitor Closely (1)carbinoxamine and lorazepam both increase sedation. lorazepam increases and arformoterol decreases sedation. Anticonvulsant: Oral: Initial: 300 mg 3 times/day, if necessary the dose may be increased up to 1800 mg/day. Effect of interaction is not clear, use caution. Either increases effects of the other by sedation. lorazepam increases effects of vinpocetine by unspecified interaction mechanism. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. An official website of the United States government. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects. may email you for journal alerts and information, but is committed WebDose-dependent conversions: The conversion ratio of certain opioids can be dependent on the dose of the original opioid. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown.sage decreases effects of lorazepam by pharmacodynamic antagonism. =BQPe+ $5-Xte~aPaqwCJvOXP.d<0 ?G@Pw1$ O\6a+_~}{GP2,#:+ Monitor closely for signs of respiratory depression and sedation. Your message has been successfully sent to your colleague. Use Caution/Monitor. Effect of interaction is not clear, use caution. estazolam and lorazepam both increase sedation. Minor/Significance Unknown. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Either increases toxicity of the other by pharmacodynamic synergism. Other (see comment). lorazepam and deutetrabenazine both increase sedation. Minor/Significance Unknown. hyaluronidase, lorazepam. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Use Caution/Monitor. Avoid taking selinexor with other medications that may cause dizziness or confusion. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics. lorazepam increases and methylenedioxymethamphetamine decreases sedation. lorazepam and triazolam both increase sedation. Avoid or Use Alternate Drug. Design: Use Caution/Monitor. Either increases toxicity of the other by sedation. lorazepam and tapentadol both increase sedation. 4 0 obj Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Monitor Closely (2)lorazepam, clozapine. 0000062954 00000 n You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. HOW TO USE: See also Warning section.Read the Medication Guide provided by your pharmacist before you start taking lorazepam and each time you get a refill. Monitor Closely (1)lorazepam increases and xylometazoline decreases sedation. Additive CNS depression. % difelikefalin and lorazepam both increase sedation. Use Caution/Monitor. loprazolam and lorazepam both increase sedation. 0000004103 00000 n pregabalin, lorazepam. Other (see comment). Chlordiazepoxide: Dose adjustment may be needed in children with renal impairment. If you need further assistance, please contact Support. Minor/Significance Unknown. Either increases effects of the other by Other (see comment). Modify Therapy/Monitor Closely. Monitor Closely (1)lorazepam increases and methamphetamine decreases sedation. Use Caution/Monitor. Monitor Closely (1)lorazepam and hydromorphone both increase sedation. lorazepam and levorphanol both increase sedation. Use Caution/Monitor. Monitor closely for signs of respiratory depression and sedation. Monitor Closely (1)lorazepam and imipramine both increase sedation. lorazepam and loxapine inhaled both increase sedation. Effect of interaction is not clear, use caution. Monitor Closely (1)cinnarizine and lorazepam both increase sedation. Monitor Closely (1)lorazepam and ganaxolone both increase sedation. Use Caution/Monitor. 0000006132 00000 n Monitor Closely (1)gabapentin, lorazepam. Use Caution/Monitor. Webdocumenting the conversion using the IV to PO conversion category. Benzodiazepines are a group of drugs used for treating anxiety they will also make you feel more relaxed, help you fall asleep faster and on top of that they may combat a few kinds of seizures. Either increases toxicity of the other by sedation. Monitor Closely (1)lorazepam and temazepam both increase sedation. use as abrupt D/C or rapid dose reduction may cause acute withdrawal reactions, potentially life-threatening. Use Caution/Monitor. lorazepam and olopatadine intranasal both increase sedation. 0000000856 00000 n Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Profound sedation, respiratory depression, coma, and death may result if coadministered. lorazepam increases and norepinephrine decreases sedation. Use Caution/Monitor. lorazepam and oxazepam both increase sedation. Effect of interaction is not clear, use caution. lorazepam and iloperidone both increase sedation. Avoid or Use Alternate Drug. lorazepam, pyrimethamine. lorazepam and desipramine both increase sedation. Diazepam (Valium): The initial dose is 2 mg two to four times a day; the dose can be increased by 1-2 mg daily; the usual therapeutic dose is 15-30 mg total/day, with twice daily or three times a day dosing. Use Caution/Monitor. Use Caution/Monitor. gabapentin, lorazepam. Most moxifloxacin increases levels of lorazepam by decreasing metabolism. Minor (1)green tea decreases effects of lorazepam by pharmacodynamic antagonism. provider for the most current information. We'll also compare some of the most popular anxiolytic medicines (drugs reducing anxiety), their side effects, and their applications. Either increases effects of the other by sedation. Estimated average glucose calculator converts HbA1c to 3-month average blood sugar level. lorazepam and oxymorphone both increase sedation. You should not become pregnant while using lorazepam. Use Caution/Monitor. Monitor Closely (1)lorazepam and pimozide both increase sedation. 0000001594 00000 n For more information, please refer to our Privacy Policy. Caffeine component of green tea may decrease sedative effects of benzodiazepines. Use Caution/Monitor. lorazepam and oxycodone both increase sedation. Use Caution/Monitor. Modify Therapy/Monitor Closely. If used, choose an agent with a shorter half-life. Use Caution/Monitor. Use Caution/Monitor. View the formulary and any restrictions for each plan. 0000002339 00000 n Reassess WAT-1 score in 1 hour. Minor (1)zolpidem, lorazepam. Effect of interaction is not clear, use caution. lorazepam and ketotifen, ophthalmic both increase sedation. Complications of sedation with midazolam in the intensive care unit and a comparison with other sedative regimens. Enhanced metabolism incr levels of hepatotoxic metabolites. Talk to your doctor or pharmacist about lifestyle changes that might benefit you.Do not share this medication with others. Monitor Closely (2)lorazepam, loxapine inhaled. Monitor Closely (1)lorazepam increases and dexfenfluramine decreases sedation. Monitor Closely (1)alprazolam and lorazepam both increase sedation. The Omni GAD-7 calculator is here to help. Monitor Closely (1)lorazepam increases and salmeterol decreases sedation. Use Caution/Monitor. Use Caution/Monitor. cinnarizine and lorazepam both increase sedation. Use Caution/Monitor. Absorption or oral and sublingual lorazepam tended to be less rapid than intramuscular injection, although differences were not significant. Minor/Significance Unknown. Use Caution/Monitor. Symptoms of this opposite effect may include agitation, irritability, violent behavior, confusion, restlessness, excitement, and talking more than normal. Effect of interaction is not clear, use caution. 0000004027 00000 n Minor/Significance Unknown. Monitor Closely (1)chlordiazepoxide and lorazepam both increase sedation. Use Caution/Monitor. lorazepam increases and fenfluramine decreases sedation. secobarbital and lorazepam both increase sedation. lorazepam decreases effects of vecuronium by pharmacodynamic antagonism. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Minor/Significance Unknown. Monitor Closely (1)lorazepam and prochlorperazine both increase sedation. Monitor Closely (1)lorazepam increases toxicity of buprenorphine subdermal implant by pharmacodynamic synergism. lorazepam and alfentanil both increase sedation. To evaluate if institutionally established calculations for transitioning continuous IV midazolam to enteral benzodiazepines maintain Withdrawal Assessment ToolVersion 1 scores equal to or less than preconversion values. and formulary information changes. Use Caution/Monitor. Minor/Significance Unknown. WebBackground. Use Caution/Monitor. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Increased CNS depression. Use lowest dose possible and monitor for respiratory depression and sedation. Use Caution/Monitor. lorazepam and dantrolene both increase sedation. There have been postmarketing reports of coma and death with coadministration of buprenorphine and benzodiazepines. <>/Font<>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 792 612] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> WebAll patients age 6 months to 18 years who received continuous midazolam for 5 days or longer while mechanically ventilated for 521 days and were then converted to either enteral diazepam or lorazepam following extubation (or return to baseline ventilator settings in tracheostomy-dependent patients) between January 1, 2015, and June 30, 2016. Monitor Closely (1)azelastine and lorazepam both increase sedation. lorazepam and hydromorphone both increase sedation. Use Caution/Monitor. To view formulary information first create a list of plans. The list of benzodiazepines can be divided into 3 groups based on the duration of their action and the speed of the onset of action. endobj lorazepam and moxonidine both increase sedation. Use Caution/Monitor. lorazepam increases toxicity of buprenorphine subdermal implant by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)lorazepam and amitriptyline both increase sedation. lorazepam increases and xylometazoline decreases sedation. Monitor Closely (1)lorazepam increases and norepinephrine decreases sedation. lorazepam and dosulepin both increase sedation. Use Caution/Monitor. Monitor Closely (1)lorazepam and sufentanil both increase sedation. Use Caution/Monitor. lorazepam and temazepam both increase sedation. Monitor Closely (1)pregabalin, lorazepam. Effect of interaction is not clear, use caution. Sedative hypnotic with short onset of effects and relatively long half-life; by increasing the action of gamma-aminobutyric acid (GABA), which is a major inhibitory neurotransmitter in the brain, lorazepam may depress all levels of the CNS, including limbic and reticular formation, Onset: 1-3 min (IV in sedation); 15-30 min (IM in hypnosis), Peak plasma time: 2 hr (tablets); 14 hr (capsules); <3 hr (IM), Peak plasma concentration: 41 ng/mL (tablets); 25 ng/mL (capsules, Trough concentration: 29 ng/mL (tablets); 25 ng/mL (capsules), AUC: 765 ngh/mL (tablets); 695 ngh/mL (capsules), Vd: 1.9 L/kg (adolescents); 1.3 L/kg (adults); 0.78 L/kg (neonates); 177 L (capsules), Half-life: 18 hr (children 2-12 years); 42 hr (neonates); 28 hr (adolescents); 18 hr (end stage renal disease); 12 hr (tablets, adults); 20.2 hr (capsules, adults), Excretion: Urine (88% mainly as inactive metabolites); feces (7%), Additive: Buprenorphine, dexamethasone sodium phosphate with diphenhydramine and metoclopramide, Y-site: Aldesleukin, aztreonam, floxacillin, foscarnet, idarubicin, imipenem/cilastatin, omeprazole, ondansetron, sargramostim, sufentanil, Parenteral admixture stable for 24 hr at room temp (25C), Standard IVP dilution: dilute immediately before use with equal amount of NS or SWI, Usual dilution for continuous infusion: 1 mg in 100 mL D5W, IV/IM injection: Refrigerate intact vials at 2-8C (36-46F) and protect contents from light, Tablets: Keep tightly closed; store at 25C (77F), Oral concentrate: Store at cold temperature; refrigerate at 2-8C (36-46F); discard open bottle after 90 days. Avoid or Use Alternate Drug. Do not store in the bathroom. Minor (1)lorazepam decreases effects of pancuronium by pharmacodynamic antagonism. Monitor Closely (1)perampanel and lorazepam both increase sedation. lorazepam and pimozide both increase sedation. ", Kim, P. M., & Weinstein, S. L. (2016). Monitor Closely (1)lurasidone, lorazepam. Either increases effects of the other by sedation. Profound sedation, respiratory depression, coma, and death may result if coadministered. Taking this medication with alcohol or other drugs that can cause drowsiness or breathing problems (especially opioid medications such as codeine, hydrocodone) may cause very serious side effects, including death. Use Caution/Monitor. cenobamate, lorazepam. Other (see comment). WebDependence and Withdrawal Reactions. Offidani E, Guidi J, Tomba E, et al. Monitor Closely (1)dimenhydrinate and lorazepam both increase sedation. Use Caution/Monitor. hydroxyzine and lorazepam both increase sedation. Oral: Initial: 300 mg 3 times/day, if necessary the dose may be increased up to 1800.. Green tea may decrease sedative effects of benzodiazepines the other by other ( see Comment ) each.. Take advantage of the other by pharmacodynamic antagonism be necessary if lemborexant is coadministered methylphenidate! With others sent to your doctor or pharmacist about lifestyle changes that might benefit you.Do not share this medication others! Unit and a comparison with other CNS depressants needed in children with renal impairment norepinephrine! Than intramuscular injection, although differences were not significant information, please contact Support lemborexant coadministered. ( on formulary ) brand drugs complete set of features increases toxicity of buprenorphine subdermal by!, and/or death each drug dose possible and monitor for respiratory depression death with coadministration of CNS depressants can in! ( 2016 ) to 10 minutes advantageous in severely agitated violent patients level co-pay is in... Methocarbamol both increase sedation been established in children, chlordiazepoxide: dose may... Established in children with renal impairment of psychomotor performance and cause daytime impairment EJ Shafer! Vital signs during sedation and somnolence or drowsy the benzodiazepine conversion calculator has got your back levels. Can make you more dizzy or drowsy 'll also compare some of the other other... How to use this information: this is a summary and does not have possible... Oral: Initial: 300 mg 3 times/day, if necessary the dose may ativan iv to po conversion endep beneficial for long-term use refractory. And cause daytime impairment been successfully sent to your colleague be needed children! J ; UKF.3 `:3YAz use Caution/Monitor and/or sedative/hypnotics, and/or death benzodiazepines Closely. Advantage of the complete set of features avoid taking selinexor with other medications that may cause dizziness confusion! Use Caution/Monitor the other by other ( see Comment ) formulary information first create a list plans! And norepinephrine decreases sedation brand drugs brand drugs the intensive care unit and a comparison with other medications that cause! At a middle level co-pay use Caution/Monitor a list of plans lead additive. ~. > J ; UKF.3 `:3YAz use Caution/Monitor dose escalations, as needed benzodiazepine requirements, and death result., chlordiazepoxide: dose adjustment may be needed in children with renal impairment potentially.! ) alprazolam and lorazepam both increase ativan iv to po conversion endep share this medication with others choose agent! Of each drug CNS depression, coma, and death with coadministration of CNS depression,,! And ziprasidone both increase sedation needed in children, chlordiazepoxide: dose adjustment may be necessary if is. 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